Phase 2 Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury

Principal Investigator:

Charles S. Cox, Jr. , M.D., University of Texas Health Science Center at Houston (UTHealth)

Co-Investigators:

Linda Ewing-Cobbs, Ph.D., University of Texas Health Science Center at Houston (UTHealth)

Jenifer Juranek, Ph.D., University of Texas Health Science Center at Houston (UTHealth)

Funding Agency:

National Institute of Neurological Diseases and Stroke/National Institutes of Health

Description of Project:

The proposed Phase 2 clinical trial will examine the effects of using bone marrow derived cells to treat severe traumatic brain injury in children. The study will test if these cells preserve injured brain tissue after traumatic injury. Preservation of brain tissue is associated with improvement in functional and cognitive outcomes. This study is designed as a prospective, randomized, placebo-controlled, blinded Phase 2 safety/biological activity study.

Research Site:

University of Texas Health Science Center at Houston

Timeline:

2013 - 2018