Autologous Cell Therapies for Cerebral Palsy

Principal Investigator:

Charles S. Cox, Jr. , M.D., University of Texas Health Science Center at Houston (UTHealth)

Co-Investigator:

Jenifer Juranek, Ph.D., University of Texas Health Science Center at Houston (UTHealth)

Funding Agency:

TIRR Foundation

CBR, Inc.

Let’s Cure CP Foundation

Description of Project:

This is a randomized, blinded, placebo-controlled, cross-over study designed to treat cerebral palsy in pediatric patients with an infusion of autologous bone marrow mononuclear cells or autologous umbilical cord blood cells. Neuroimaging data are acquired on a 3T GE clinical MRI scanner at three time points: baseline, 6 months, and 12 months post infusion. Quantitative analysis of neuroimaging data targets major white matter pathways such as the corpus callosum and the corticospinal tract. These quantitative measures are then correlated with such functional outcomes as gross motor function and a battery of neuropsychological assessments.

Research Site:

University of Texas Health Science Center at Houston

Timeline:

2013-2016